:root{--bg: #FAF8F4;--surface: #FFFFFF;--surface-sunken: #F2EFE8;--border: #E4DFD5;--ink: #1C2826;--ink-soft: #5A6360;--primary: #0E6E64;--primary-soft: #D7EAE6;--accent: #B4541E;--tier-p: #B3261E;--tier-lp: #C9662B;--tier-vus: #9A8C66;--tier-lb: #3A7CA5;--tier-b: #2F6E54;--font-display: "Fraunces", Georgia, serif;--font-body: "Public Sans", system-ui, sans-serif;--font-mono: "JetBrains Mono", ui-monospace, monospace;--space-1: 4px;--space-2: 8px;--space-3: 12px;--space-4: 16px;--space-5: 24px;--space-6: 32px;--space-7: 48px;--radius-control: 6px;--radius-card: 10px;--shadow-soft: 0 1px 3px rgba(28, 40, 38, .06);--motion-quick: .15s ease-out;--motion-base: .2s ease-out;--motion-reveal: .25s ease-out}@media (prefers-reduced-motion: reduce){:root{--motion-quick: 0ms;--motion-base: 0ms;--motion-reveal: 0ms}}*,*:before,*:after{box-sizing:border-box}html,body,#root{height:100%}body{margin:0;background:var(--bg);color:var(--ink);font-family:var(--font-body);font-size:14px;line-height:1.5;-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility;font-feature-settings:"ss01","cv11"}h1,h2,h3,h4{font-family:var(--font-display);font-weight:500;letter-spacing:-.005em;color:var(--ink);margin:0}h1{font-size:32px;line-height:1.15}h2{font-size:22px;line-height:1.2}h3{font-size:17px;line-height:1.3}.mono,code,kbd,samp{font-family:var(--font-mono);font-variant-numeric:tabular-nums}a{color:var(--primary);text-decoration:none}a:hover{text-decoration:underline}button{font:inherit;cursor:pointer;background:var(--surface);color:var(--ink);border:1px solid var(--border);border-radius:var(--radius-control);padding:6px 12px;transition:background var(--motion-quick),border-color var(--motion-quick)}button:hover{background:var(--surface-sunken)}button.primary{background:var(--primary);color:#fff;border-color:var(--primary)}button.primary:hover{background:#0c5d54}input,textarea,select{font:inherit;background:var(--surface);color:var(--ink);border:1px solid var(--border);border-radius:var(--radius-control);padding:6px 10px}input:focus,textarea:focus,select:focus{outline:2px solid var(--primary-soft);outline-offset:1px;border-color:var(--primary)}.app{display:grid;grid-template-columns:220px 1fr;min-height:100vh}.rail{background:var(--surface);border-right:1px solid var(--border);padding:var(--space-5) var(--space-4);display:flex;flex-direction:column;gap:var(--space-4)}.rail .wordmark{font-family:var(--font-display);font-weight:500;font-size:22px;letter-spacing:-.01em}.rail nav{display:flex;flex-direction:column;gap:2px}.rail nav a{color:var(--ink-soft);padding:6px 10px;border-radius:var(--radius-control)}.rail nav a.active{color:var(--ink);background:var(--surface-sunken)}.rail nav a:hover{background:var(--surface-sunken);text-decoration:none}.main{padding:var(--space-5) var(--space-6)}.topbar{display:flex;align-items:center;gap:var(--space-4);padding-bottom:var(--space-4);border-bottom:1px solid var(--border);margin-bottom:var(--space-5)}.topbar h1{flex:1;font-size:24px}.pill{display:inline-flex;align-items:center;padding:2px 8px;border-radius:999px;border:1px solid var(--border);background:var(--surface);font-size:12px;color:var(--ink-soft)}.table{width:100%;border-collapse:collapse}.table th,.table td{text-align:left;padding:10px 12px;border-bottom:1px solid var(--border);font-size:13px}.table th{color:var(--ink-soft);font-weight:500}.table td.num,.table th.num{text-align:right;font-family:var(--font-mono);font-variant-numeric:tabular-nums}.table tr:hover{background:var(--surface-sunken)}.table tr.reclass td:first-child{border-left:3px solid var(--accent);padding-left:9px}.card{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-card);box-shadow:var(--shadow-soft);padding:var(--space-5)}.tier-chip{display:inline-flex;align-items:center;justify-content:center;min-width:32px;padding:2px 8px;border-radius:var(--radius-control);font-family:var(--font-mono);font-weight:600;font-size:12px;letter-spacing:.02em;color:#fff}.tier-chip.outlined{background:transparent;border:1.5px solid currentColor}.tier-chip.tier-P{background:var(--tier-p)}.tier-chip.tier-LP{background:var(--tier-lp)}.tier-chip.tier-VUS{color:var(--tier-vus)}.tier-chip.tier-LB{background:var(--tier-lb)}.tier-chip.tier-B{background:var(--tier-b)}.ledger{display:grid;grid-template-columns:1fr;gap:var(--space-4)}.ledger-group{border:1px solid var(--border);border-radius:var(--radius-card);overflow:hidden}.ledger-group.ledger-warm{background:linear-gradient(180deg,rgba(180,84,30,.03),transparent 40%)}.ledger-group.ledger-cool{background:linear-gradient(180deg,rgba(58,124,165,.04),transparent 40%)}.ledger-group-header{display:flex;justify-content:space-between;align-items:baseline;padding:var(--space-3) var(--space-4);font-family:var(--font-display);font-size:14px;letter-spacing:.01em;border-bottom:1px solid var(--border)}.ledger-count{font-family:var(--font-mono);font-size:11px;color:var(--ink-soft)}.ledger-list{list-style:none;margin:0;padding:0}.ledger-row{border-bottom:1px solid var(--border);line-height:1.6}.ledger-row:last-child{border-bottom:none}.ledger-row-head{width:100%;display:grid;grid-template-columns:56px 96px 1fr 16px;gap:var(--space-3);align-items:baseline;padding:10px 16px;background:transparent;border:0;border-radius:0;text-align:left}.ledger-row-head:hover:not(:disabled){background:var(--surface-sunken)}.ledger-row-head:disabled{cursor:default}.ledger-row.muted .ledger-row-head{color:var(--ink-soft);opacity:.55}.ledger-row.muted .ledger-summary{text-decoration:line-through;text-decoration-thickness:1px}.ledger-criterion{font-weight:600;font-size:12px;letter-spacing:.04em}.ledger-strength{font-size:12px;color:var(--ink-soft)}.ledger-row.fired .ledger-strength{color:var(--ink)}.ledger-summary{font-size:13px}.ledger-chev{font-size:11px;color:var(--ink-soft)}.ledger-row-body{padding:4px 16px 12px 184px;font-size:13px;color:var(--ink-soft);display:grid;gap:4px}.ledger-row-body>div{display:grid;grid-template-columns:80px 1fr;gap:12px}.ledger-label{color:var(--ink-soft);font-size:11px;text-transform:uppercase;letter-spacing:.08em}.popfreq{display:flex;flex-direction:column;gap:8px}.popfreq-axis{display:flex;justify-content:space-between;font-size:11px;color:var(--ink-soft);font-family:var(--font-mono);padding-left:116px;padding-right:64px}.popfreq-threshold-label{color:var(--accent)}.popfreq-list{list-style:none;padding:0;margin:0;display:grid;gap:6px}.popfreq-row{display:grid;grid-template-columns:108px 1fr 56px;align-items:center;gap:8px}.popfreq-label{font-size:12px;color:var(--ink-soft)}.popfreq-track{position:relative;height:16px;background:var(--surface-sunken);border-radius:8px;overflow:hidden}.popfreq-bar{position:absolute;top:4px;height:8px;left:0;background:var(--primary);opacity:.5;border-radius:4px}.popfreq-bar.over{background:var(--accent);opacity:.65}.popfreq-dot{position:absolute;top:3px;width:10px;height:10px;border-radius:50%;background:var(--ink);transform:translate(-50%)}.popfreq-threshold{position:absolute;top:0;bottom:0;width:1px;background:var(--accent);opacity:.7}.popfreq-value{font-size:12px;text-align:right}.gauges{list-style:none;margin:0;padding:0;display:grid;grid-template-columns:repeat(2,1fr);gap:12px}.gauge{display:grid;grid-template-columns:1fr 60px;grid-template-rows:auto auto;column-gap:8px;align-items:center}.gauge-label{font-size:12px;color:var(--ink-soft);grid-column:1}.gauge-value{font-size:13px;text-align:right;grid-row:1;grid-column:2}.gauge-track{position:relative;height:6px;background:var(--surface-sunken);border-radius:3px;grid-column:1 / -1;grid-row:2}.gauge-fill{position:absolute;left:0;top:0;bottom:0;background:var(--primary);opacity:.4;border-radius:3px}.gauge.over .gauge-fill{background:var(--tier-lp);opacity:.7}.gauge-threshold{position:absolute;top:-2px;bottom:-2px;width:1px;background:var(--ink);opacity:.5}.gauge-empty .gauge-value{color:var(--ink-soft)}.pedigree{display:flex;flex-direction:column;align-items:center;gap:8px;padding:var(--space-4);background:var(--surface-sunken);border-radius:var(--radius-card)}.pedigree-row{display:flex;gap:var(--space-5);align-items:center}.pedigree-link{width:1px;background:var(--ink-soft);height:24px}.ped-node{width:44px;height:44px;display:grid;place-items:center;background:var(--surface);border:1.5px solid var(--ink);cursor:pointer;position:relative;font-size:10px;color:var(--ink-soft)}.ped-node.male{border-radius:0}.ped-node.female{border-radius:50%}.ped-node.unknown{transform:rotate(45deg)}.ped-node.unknown>span{transform:rotate(-45deg)}.ped-node.affected{background:var(--ink);color:#fff}.ped-node.missing{border-style:dashed;border-color:var(--accent);color:var(--accent);background:#b4541e0a}.ped-node.missing.affected{background:#b4541e2e;color:var(--accent)}.ped-node.selected{outline:2px solid var(--primary);outline-offset:2px}.ped-selected{margin-top:12px;width:100%;max-width:460px;display:grid;gap:8px;padding:10px 12px;background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-control);font-size:12px}.ped-selected-title{display:flex;align-items:baseline;gap:8px;font-family:var(--font-display);font-size:14px}.ped-selected-sub{color:var(--ink-soft);font-family:var(--font-body);font-size:11px}.ped-selected-row{display:flex;align-items:center;gap:6px}.ped-selected-label{color:var(--ink-soft);width:32px;font-size:11px}.ped-hint{font-size:12px;color:var(--ink-soft);margin:8px 0 0}.ped-node.proband:after{content:"";position:absolute;left:-6px;bottom:-6px;width:10px;height:10px;border-left:1.5px solid var(--accent);border-bottom:1.5px solid var(--accent)}.consang-line{border-top:2px double var(--ink);width:80px}.hpo-chip{display:inline-flex;align-items:center;gap:6px;padding:4px 10px;border-radius:999px;font-size:12px;font-family:var(--font-mono)}.hpo-chip.confirmed{background:var(--primary-soft);color:var(--ink);border:1px solid transparent}.hpo-chip.suggested{background:transparent;color:var(--ink-soft);border:1px dashed var(--border)}.hpo-chip.suggested button{background:transparent;border:0;color:var(--primary);padding:0;font-size:14px}.hpo-chip .remove{background:transparent;border:0;color:var(--ink-soft);padding:0}.dropzone{display:grid;gap:4px;padding:16px;border:1.5px dashed var(--border);border-radius:var(--radius-card);background:var(--surface);text-align:center;font-size:13px;color:var(--ink-soft)}.dropzone strong{color:var(--ink);font-family:var(--font-body)}.drop{display:grid;gap:6px;padding:16px;border:1.5px dashed var(--border);border-radius:var(--radius-card);background:var(--surface);text-align:center;font-size:13px;color:var(--ink-soft);min-height:132px;cursor:pointer;transition:border-color var(--motion-quick),background var(--motion-quick);position:relative}.drop:hover{border-color:var(--primary);background:var(--surface-sunken)}.drop.drop-over{border-color:var(--primary);background:var(--primary-soft);border-style:solid}.drop.drop-error{border-color:var(--accent)}.drop-label{color:var(--ink);font-family:var(--font-body)}.drop-label strong{font-weight:500}.drop-empty{color:var(--ink-soft);display:grid;gap:4px;place-self:center}.drop-formats{font-size:11px;opacity:.7}.drop-staged{display:grid;gap:6px;place-content:center}.drop-filename{font-size:12px;color:var(--ink);word-break:break-all}.drop-meta{display:flex;gap:8px;justify-content:center;align-items:center;font-size:11px;color:var(--ink-soft)}.drop-err{color:var(--accent);font-size:11px}.drop-clear{position:absolute;top:6px;right:6px;background:transparent;border:0;color:var(--ink-soft);padding:2px 6px;font-size:11px;cursor:pointer}.drop-clear:hover{color:var(--accent)}.kind-badge{display:inline-block;padding:1px 6px;border:1px solid;border-radius:4px;font-size:10px;font-weight:600;letter-spacing:.06em}.sample-map{font-size:11px;color:var(--ink-soft);padding:4px 8px;border-radius:4px;background:var(--surface-sunken);display:flex;gap:8px;align-items:center;flex-wrap:wrap}.sample-map.ok{background:#0e6e640f;color:var(--primary)}.sample-map.warn{background:#b4541e0f;color:var(--accent)}.sample-map .warn-tag{font-size:10px;padding:1px 5px;border-radius:3px;background:var(--accent);color:#fff}.banner{display:block;margin-top:12px;padding:8px 12px;border-radius:var(--radius-control);font-size:12px}.banner-info{background:var(--primary-soft);color:var(--ink)}.banner-warn{background:#b4541e14;color:var(--accent);border:1px solid rgba(180,84,30,.25)}.run-monitor{padding:var(--space-5)}.run-monitor-head{display:flex;justify-content:space-between;align-items:start;gap:16px;margin-bottom:16px}.run-monitor-eyebrow{font-size:11px;color:var(--ink-soft);text-transform:uppercase;letter-spacing:.08em}.run-pill{display:inline-flex;align-items:center;padding:4px 10px;border-radius:999px;border:1px solid var(--border);font-size:12px;font-weight:500}.run-pill-queued{background:var(--surface-sunken);color:var(--ink-soft)}.run-pill-running{background:var(--primary-soft);color:var(--primary);border-color:var(--primary)}.run-pill-ready{background:#2f6e5414;color:var(--tier-b);border-color:var(--tier-b)}.run-pill-error{background:#b3261e14;color:var(--tier-p);border-color:var(--tier-p)}.run-pill-unknown{color:var(--ink-soft)}.run-progress{height:4px;border-radius:2px;background:var(--surface-sunken);overflow:hidden;margin-bottom:16px}.run-progress-bar{height:100%;background:var(--primary);width:0%;transition:width var(--motion-base)}.run-progress-bar.run-progress-queued{width:10%;opacity:.4}.run-progress-bar.run-progress-running{width:70%;background:linear-gradient(90deg,var(--primary) 0%,var(--primary-soft) 50%,var(--primary) 100%);background-size:200% 100%;animation:run-shimmer 1.6s linear infinite}.run-progress-bar.run-progress-ready{width:100%;background:var(--tier-b)}.run-progress-bar.run-progress-error{width:100%;background:var(--tier-p)}@keyframes run-shimmer{0%{background-position:200% 0}to{background-position:-200% 0}}@media (prefers-reduced-motion: reduce){.run-progress-bar.run-progress-running{animation:none}}.run-meta{display:flex;gap:24px;margin:0 0 16px;flex-wrap:wrap;font-size:12px}.run-meta>div{display:flex;flex-direction:column;gap:2px}.run-meta dt{color:var(--ink-soft);font-size:11px;text-transform:uppercase;letter-spacing:.06em}.run-meta dd{margin:0;font-size:13px}.run-error{margin-bottom:16px;padding:10px 12px;background:#b3261e0f;border:1px solid rgba(179,38,30,.25);color:var(--tier-p);border-radius:var(--radius-control);font-size:13px}.run-log summary{font-size:12px;color:var(--ink-soft);cursor:pointer;padding:4px 0;-webkit-user-select:none;user-select:none}.run-log pre{background:var(--ink);color:#dce6e3;font-size:11px;line-height:1.5;padding:10px 12px;border-radius:var(--radius-control);margin:6px 0 0;max-height:240px;overflow:auto;white-space:pre-wrap;word-break:break-all}.reclass-badge{display:inline-flex;align-items:center;gap:6px;padding:2px 8px;border-radius:999px;background:#b4541e14;color:var(--accent);border:1px solid rgba(180,84,30,.25);font-size:12px;font-family:var(--font-mono)}